Is Fructose Linked to Adiposity in Babies?

Completed

Conditions studied: Obesity, Metabolic Syndrome

In brief

The obesity epidemic has reached down into the infant and toddler age group. Dietary indiscretion during pregnancy, particularly in our current food environment, is a major risk factor for both gestational diabetes and neonatal macrosomia (\>4kg newborns), which is itself a risk factor for obesity and metabolic syndrome in the offspring, possibly even during childhood. Temporal increases in fructose consumption in the last two decades coincide with temporal increases weight gain during pregnancy and with increased birth weight, including a higher prevalence of macrosomic newborns. Our central hypothesis is that higher fructose consumption during pregnancy is a risk factor for infant obesity and metabolic syndrome.

Key facts

Study ID

NCT01262781

Run by

University of California, San Francisco

People needed

40

Starts

2011-01-01

Expected to finish

2013-01-01

Last updated by the study team

2014-04-10

Who can join

Age: 18 and older, up to 40. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Agreement to participate in all measurements
• Plans to remain in the area through delivery
• Ability to understand and give informed consent in either English or Spanish.

You may not qualify if…

• Presence of diabetes prior to the index pregnancy
• Presence of gestational diabetes during a previous pregnancy
• Presence of diabetes or of other chronic metabolic disease such as cardiovascular disease, active thyroid disease, liver disease, pulmonary or psychiatric disorders, HIV
• Any disorder requiring diet therapy (i.e., renal insufficiency)
• Multiple gestation
• Prior history of intrauterine growth retardation
• Use of substances known to cause intrauterine growth retardation (e.g., smoking or drug use). -
• Once recruited, any ultrasonographic evidence of intrauterine growth retardation during the course of the pregnancy would also lead to exclusion.

Where it is running

• San Francisco General Hospital — San Francisco, California, United States

Full record on ClinicalTrials.gov

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