Cardiac Hemodynamics in Overlap Syndrome (COPD With Obstructive Sleep Apnea)
Withdrawn before enrolling · Phase 1/Phase 2
Conditions studied: Chronic Obstructive Airway Disease
In brief
Patients with both sleep apnea and COPD have overlap syndrome, but their optimal management is not known. We plan to conduct a randomized trial of of bi-level PAP vs. night time oxygen to asses the impact of intervention on cardiac MRI and biomarkers.
Key facts
- Study ID
- NCT01261377
- Run by
- Brigham and Women's Hospital
- People needed
- 0
- Starts
- 2010-11-01
- Expected to finish
- 2011-09-01
- Last updated by the study team
- 2017-01-12
Who can join
Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Both men and women with age more than 18 years.
- Known diagnosis of COPD (GOLD stage 2 or higher).
You may not qualify if…
- Already using CPAP or BPAP device.
- Estimated GFR <30 ml/min/1.73 m2 or on hemodialysis.
- Women known to be pregnant or planning to be pregnant in next 6 months.
- Cardiac pacemaker, metallic heart valves, metallic implants, claustrophobic.
- Chronic atrial fibrillation or frequent premature ventricular contractions.
- Using lipid-lowering medications, aspirin, oral steroids, steroid-sparing medications or anti-oxidant vitamin supplements.
- If taking sildenafil or related drugs, unable to stop it within 48 hours of the study visit.
- Contraindications to stress cardiac testing: acute myocardial infarction within 48 hours, unstable angina not yet stabilized with medical therapy, ongoing chest pain, active broncho-constriction, uncontrolled cardiac arrhythmia, symptomatic severe aortic stenosis, aortic dissection, acute pulmonary embolism or pericarditis.
- Uncontrolled COPD or acute COPD exacerbation.
- Known chronic inflammatory diseases like lupus or active infection.
Where it is running
- Massachussets General Hospital — Boston, Massachusetts, United States
- Brigham and Women's Hospital — Boston, Massachusetts, United States
Full record on ClinicalTrials.gov
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