Hypertensive Ambulatory Trial to Compare the Efficacy of HCTZ and Lisinopril

Completed · Not applicable

Conditions studied: Hypertension, Grade 1, Hypertension Treatment, N of 1 Study Design, Hypertension

In brief

The purpose of this trial is to evaluate if an objective clinical decision of anti-hypertensive therapy can be made using an N-of-1 (single patient) trial design.

Key facts

Study ID

NCT01258764

Run by

Scripps Translational Science Institute

People needed

2

Starts

2010-11-01

Expected to finish

2014-03-01

Last updated by the study team

2015-05-20

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosis of Grade 1 Hypertension
• Treatment naïve
• GFR > 60 within previous 3 months
• Urinary microalbumin level normal during previous 3 months

You may not qualify if…

• Pregnancy (Fetal morbidity and mortality may occur with the use of ACE inhibitors.)
• Uncontrolled Hyperthyroidism
• Sleep Apnea
• Primary Aldosteronism
• Renovascular Disease
• Cushing's Syndrome or steroid therapy
• No evidence of end organ damage
• EKG with evidence of LVH within previous 3 months
• Collagen Vascular Disease
• Current Smoker

Where it is running

• Scripps Clinic — La Jolla, California, United States

Full record on ClinicalTrials.gov

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