A Study to Compare the Effects of Different Sized Particles on Cells in the Nose

Completed · Phase 1 · Has a placebo group

Conditions studied: Hypersensitivity, Immediate, Atopic Hypersensitivity

In brief

The goal of this study is to see how the type and size of particles found in air pollution affects inflammation in the nose in people who are skin test positive to at least one allergen. It has been observed that pollution makes allergies worse. It has also been suggested that very small particles may affect allergies more than larger particles.

Key facts

Study ID

NCT01257191

Run by

University of California, Los Angeles

People needed

25

Starts

2010-04-01

Expected to finish

2012-01-01

Last updated by the study team

2017-01-11

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Previously determined high inflammatory responders to Diesel Exhaust Particles
• Previously determined atopy as demonstrated by allergy skin testing
• Asymptomatic on day of challenge.

You may not qualify if…

• History of lung problems (including asthma), bleeding, neuromuscular, liver, kidney or heart disorders.
• History of anaphylaxis.
• Recent upper respiratory infection (less than 4 weeks prior to study) or other active infection.
• Active smoker or smoker in the past 2 years.
• Treatment with topical nasal steroids (< 1 month), systemic steroids (<1 month), oral antihistamines (< 1 week) prior to any nasal challenge.
• Use of leukotriene receptor antagonist (< 1 month ) prior to any nasal challenge
• Intranasal antihistamine or cromolyn use < 1 week prior to any nasal challenge .
• History of treatment with allergy immunotherapy.
• Inability to perform nasal lavage.
• Inability to give written informed consent
• Pregnancy

Where it is running

• University of California, Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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