Nerve Growth Factor in Chronic Pancreatitis

Completed

Conditions studied: Chronic Pancreatitis

In brief

This study is to understand the role of nerve growth factor(NGF) and other cytokines in the pancreatic fluid of patients with chronic pancreatitis. Hypothesis: 1. Pain does not correlate with changes in the PD morphology suggesting that pain in CP is not only a mechanical problem 2. Pain in CP correlates better with the levels of NGF in the pancreatic juice. NGF is variably expressed in different morphological stages of CP and regulates the sensitivity of the peptidergic nociceptors and is upregulated in pancreatic inflammation.

Key facts

Study ID

NCT01255917

Run by

Virginia Commonwealth University

People needed

38

Starts

2008-02-01

Expected to finish

2011-08-01

Last updated by the study team

2016-03-07

Who can join

Age: 18 and older, up to 70. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients with established CP and none of the exclusion criteria mention below.

You may not qualify if…

• Failure to obtain consent.
• Any comorbid condition with expected survival < 1 year.
• Patients with pacemaker, implanted metallic prosthesis or other contraindications to do MRCP.
• Patients < 18 years of age at time of consent

Where it is running

• Virginia Commonwealth University Medical Center — Richmond, Virginia, United States

Full record on ClinicalTrials.gov

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