Frequency of EGFR Mutations in Latinos/Hispanics With Non-Small Cell Lung Cancer

Completed

Conditions studied: Non-Small-Cell Lung Carcinoma

In brief

Background: \- Research has shown that the Epidermal Growth Factor Receptor (EGFR) gene is an important target for personalized lung cancer treatment. Individuals who have mutations in the EGFR gene have better responses when treated with certain personalized or targeted therapies compared with conventional chemotherapy. These mutations are more frequent in females with lung cancer who have never smoked, and different ethnic groups have different levels of frequency of the mutations. Researchers are interested in collecting more information on EGFR genetic mutations in Hispanics/Latinos with lung cancer, comparing the frequency of these mutations in males and females and smokers and nonsmokers. This study may lead to better, more personalized care approaches for all individuals with lung cancer. Objectives: \- To study the frequency of Epidermal Growth Factor Receptor mutations in Hispanic/Latino individuals who have been diagnosed with non-small cell lung cancer. Eligibility: \- Hispanic or Latino individuals who have been diagnosed with non-small cell lung cancer and who have lung tissue from a previous biopsy or surgery available for research purposes. Design: * Participants will provide consent for researchers to examine lung tissue collected from a previous biopsy or surgery. * Treatment will not be provided as part of this protocol.

Key facts

Study ID

NCT01255150

Run by

National Cancer Institute (NCI)

People needed

15

Starts

2010-12-01

Expected to finish

2015-04-29

Last updated by the study team

2019-11-21

Who can join

Age: 2 and older, up to 100. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Patients born in Europe, Asia, Africa or Australia are excluded.

Where it is running

• Denver Health Medical Center — Denver, Colorado, United States
• National Institutes of Health Clinical Center, 9000 Rockville Pike — Bethesda, Maryland, United States
• Kettering Health Network — Kettering, Ohio, United States
• Oregon Health and Sciences Universtiy Cancer Center — Portland, Oregon, United States
• University of Texas Southwestern Medical Center — Dallas, Texas, United States
• Universidad Mayor de San Simon — Cochabamba, Bolivia
• Universidad de Colima — Colima, Mexico
• Instituto Nacional de Cancerologia — Mexico City, Mexico
• Center for Research & Development in Health Sciences — Monterrey, Mexico
• Universidad Autonoma de Queretaro — Querétaro, Mexico
• Instituto Nacional de Enfermedades Neoplasicas (INEN) — Lima, Peru
• Instituto de Oncologia Luis Razetti — Caracas, Venezuela

Full record on ClinicalTrials.gov

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