The Pathogenesis of Idiopathic Dry Eyes

Completed

Conditions studied: Dry Eye, Fibromyalgia

In brief

Dry eyes are a very common complaint. In some patients, we can identify the reason for the dryness; however, in others the dryness has no clear cause. Dryness can lead to eye irritation, redness, and sometimes changes in vision. Fibromyalgia is a condition of chronic pain that is poorly understood but seems to have a component of altered sensory processing. People with fibromyalgia tend to complain of dry and irritated eyes at a higher rate than the general population. We plan to evaluate patients with dry eye symptoms for abnormalities in sensory processing and in their autonomic nervous system. We hope to learn about possible relationships between dry eye symptoms and fibromyalgia in order to better understand and treat these conditions.

Key facts

Study ID

NCT01254201

Run by

University of Michigan

People needed

90

Starts

2008-06-01

Expected to finish

2015-12-01

Last updated by the study team

2017-03-15

Who can join

Age: 18 and older. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• Healthy Controls:
• Female over the age of 18, No symptoms of dry eyes, Must be able to read text on the computer screen and understand English, and not have a physical impairment that prevents you from completing a paper and pencil questionnaire or using a tablet computer
• Fibromyalgia:
• Female over the age of 18, No symptoms of dry eyes, Been diagnosed with fibromyalgia, Must be able to read text on the computer screen and understand English, and not have a physical impairment that prevents you from completing a paper and pencil questionnaire or using a tablet computer
• Dry Eye:
• Female over the age of 18, have symptoms of dry eyes, Must be able to read text on the computer screen and understand English, and not have a physical impairment that prevents you from completing a paper and pencil questionnaire or using a tablet computer

You may not qualify if…

• Pregnant or breast feeding, use of medicated eye drops in last month (Artificial tears ok), diagnosis of autoimmune or rheumatologic disease (e.g. rheumatoid arthritis, crohn's disease, lupus, multiple sclerosis, etc), heart condition requiring daily medications (e.g. angina, congestive heart failure), COPD or asthma requiring daily inhalers (rescue inhalers ok), history of cancer in the past 2 years (skin cancer is ok), use of oral antihistamine medications (e.g. benadryl, claritin, clarinex, zyrtec, allegra, etc), use of oral anticholinergic medications (e.g. scopolamine, ditropan, detrol, ipratropium, etc)

Where it is running

• University of Michigan Kellogg Eye Center — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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