Evaluation of the Role of Prostaglandins in Radiation-induced Mucositis

Completed

Conditions studied: Cancer of the Head and Neck, Radiotherapy

In brief

This study will evaluate the role of cyclooxygenase pathways in radiation-induced and chemoradiation-induced mucositis.

Key facts

Study ID

NCT01252498

Run by

University of Vermont

People needed

9

Starts

2010-12-01

Expected to finish

2012-09-01

Last updated by the study team

2014-02-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Histologically proven locoregional Stage 4 squamous cell carcinoma of the oral cavity, larynx, oropharynx or hypopharynx
• Receiving radiation therapy or chemoradiation therapy to the oropharynx
• Older than 18 years old
• ECOG performance status of 0-2
• Life expectancy greater than 2 months
• Signed informed consent

You may not qualify if…

• Previous chemotherapy for this malignancy
• Previous radiotherapy to the head and neck
• Other cancer diagnosis within the last 5 years except for non-melanoma skin cancer or non-metastatic prostate cancer
• Patient taking NSAIDs

Where it is running

• Fletcher Allen Health Care — Burlington, Vermont, United States

Full record on ClinicalTrials.gov

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