Histologic Assessment of the Difference Between 18F-2-fluoro-2-deoxy_D-glucose Positron Emission Mammography(PEM) and Magnetic Resonance Imaging (MRI) of the Breast

Stopped early · Not applicable

Conditions studied: Breast Cancer

In brief

Positron Emission Mammography (PEM) is a newly developed imaging examination of the breast that uses a radioactive glucose based tracer, which is a form of sugar attached to a low radiation agent, to detect cancer cells. The radioactive glucose based tracer is called fluorodeoxyglucose (FDG), and it is FDA approved. A PEM scanner is able to better detect cancer cells within the breast, more than a regular PET scanner. The PEM scanner is also FDA approved. This type of imaging may be able to see the breast cancer before it could be seen with mammograms and may be as good as or better than breast MRI. The purpose of this study is to compare the value of FDG Positron Emission Mammography (PEM) with contrast enhanced Magnetic Resonance Imaging (MRI) of the breast for patients with breast cancer. This study will also perform special pathology test to compare the FDG PEM and contrast enhanced breast MRI images with the results from the standard of care breast surgery. This may teach us more about the biology of each breast tumor.

Key facts

Study ID

NCT01249157

Run by

Memorial Sloan Kettering Cancer Center

People needed

6

Starts

2010-11-01

Expected to finish

2012-08-01

Last updated by the study team

2015-12-24

Who can join

Age: 21 and older. Sex: female. Healthy volunteers: not accepted.

You may qualify if…

• Female patients with recently diagnosed invasive or in situ breast cancer by core needle biopsy or FNA (confirmed at MSKCC) prior to enrollment.
• Patients planning treatment with mastectomy at MSKCC.
• Patients 21 years old or older.
• Patients who had or are having a breast MRI within 30 days or less of PEM.
• Patients who had or are having a digital mammogram.

You may not qualify if…

• Patients who are pregnant or breast feeding.
• Patients with prior radiation therapy or endocrine therapy.
• Patients who had a prior lumpectomy.
• Patients who are diabetic.
• Patients with moderate to end stage kidney disease.
• Patients who have a contraindication to MRI (i.e. pacemaker, metallic implants, etc).

Where it is running

• Memorial Sloan Kettering Cancer Center — New York, New York, United States

Full record on ClinicalTrials.gov

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