Comparison of Tranexamic to Epsilon Aminocaproic Acid: a Prospective Analysis of Blood Conservation in Cardiac Surgery

Completed · Not applicable

Conditions studied: Cardiopulmonary Bypass

In brief

We designed a prospective double-blinded randomized trial in an attempt to detect a difference between tranexamic acid (TXA) and epsilon aminocaproic acid (EACA) in reducing transfusion in patients undergoing cardiac surgery.

Key facts

Study ID

NCT01248104

Run by

Loma Linda University

People needed

100

Starts

2010-03-01

Expected to finish

2015-02-01

Last updated by the study team

2020-10-19

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Is the subject 18 years of age or older?
• Is the subject scheduled for primary cardiac surgery utilizing cardiopulmonary bypass(CPB)?
• Is the subject more than 30 kg ( 66 lbs)?
• Does subject understand English?

You may not qualify if…

• Does the subject have existing coagulation defects (INR > 1.5, platelets < 100 ?
• Does the subject have renal failure (defined as BUN/Cr ratio 20:1 ?
• Does the subject have severe liver disease (AST \& ALT> 3x normal) ?
• Is the subject having emergency cardiac surgery, complex aortic surgery, combination valve/CABG surgeries, or redo cardiac surgery?
• Is the subject having any procedure where CPB is not anticipated?
• Is the patient weight greater than 150 kg?

Where it is running

• Loma Linda University Medical Center — Loma Linda, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.