Early Treatment With Dexamethasone in Mild Acute Pancreatitis

Withdrawn before enrolling · Phase 2 · Has a placebo group

Conditions studied: Patients With Acute Pancreatitis

In brief

This pilot trial will evaluate the following in patients with acute pancreatitis: 1. Safety profile of early treatment with intravenous dexamethasone 2. Impact of dexamethasone on systemic inflammation in patients with acute pancreatitis 3. Provide preliminary data on potential impact of early treatment with steroids on clinical outcomes

Key facts

Study ID

NCT01247961

Run by

Brigham and Women's Hospital

People needed

0

Starts

2010-11-01

Expected to finish

2011-06-01

Last updated by the study team

2016-12-12

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age>=18 years
• Diagnosis of acute pancreatitis confirmed by at least 2 of the following:
• Typical epigastric abdominal pain
• Elevation amylase/lipase >3 times upper limit normal and/or
• Confirmatory findings on cross-sectional imaging
• Enrollment within 8 hours of presentation

You may not qualify if…

• Class II or greater NYHA heart failure
• Oxygen dependent COPD
• Chronic kidney disease>stage 2
• Cirrhosis
• Existing necrosis on abdominal CT
• Organ dysfunction prior to enrollment
• Sepsis
• Acute respiratory distress syndrome
• Malignancy not in remission for at least 5 years
• Active drug use
• Known allergy to dexamethasone
• Altered mental status
• Insulin-requiring diabetes
• Abdominal surgery within 60 days

Where it is running

• Brigham and Women's Hospital — Boston, Massachusetts, United States

Full record on ClinicalTrials.gov

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