Hypertonic Saline for Acute Bronchiolitis

Completed · Phase 4

Conditions studied: Bronchiolitis, Viral, Saline Solution, Hypertonic

In brief

The purpose of this study is to determine whether nebulized 3% hypertonic saline (HS) improves respiratory distress in children 2-23 months presenting to the emergency department (ED) with acute bronchiolitis with persistent respiratory distress after initial therapy with a trial of nebulized albuterol.

Key facts

Study ID

NCT01247064

Run by

Children's Hospital of Philadelphia

People needed

62

Starts

2010-10-01

Expected to finish

2011-12-01

Last updated by the study team

2014-08-19

Who can join

Age: 0 and older, up to 2. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age 8 weeks through 23 months
• First episode of wheezing associated with respiratory distress and upper respiratory tract infection.
• Respiratory Distress Assessment Instrument (RDAI) rating of ≥4 and ≤15 after initial albuterol nebulization per standard care
• Pediatric Emergency Medicine (PEM) physician does not plan additional bronchodilator therapy within the hour after initial assessment.
• Parental/guardian permission (informed consent)

You may not qualify if…

• Subjects with prior history of wheezing or asthma or who have received bronchodilator therapy prior to the current illness
• Chronic lung or heart disease
• Critically ill infants requiring immediate airway stabilization
• Non-English speaking parent/guardian
• Inability to take nebulized medications

Where it is running

• The Children's Hospital of Philadelphia — Philadelphia, Pennsylvania, United States

Full record on ClinicalTrials.gov

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