Aminophylline to Prevent Acute Kidney Injury in Children After Cardiac Surgery

Completed · Not applicable · Has a placebo group

Conditions studied: Acute Kidney Injury

In brief

Children with congenital heart defects often need cardiac surgery with cardiopulmonary bypass (the "heart-lung machine"). Approximately 35 to 50% of these children will have "acute kidney injury," or damage to the kidneys, after the procedure. We currently have few medications to prevent this kidney injury. The hypothesis of this study is that giving aminophylline after heart surgery can decrease the acute kidney injury.

Key facts

Study ID

NCT01245595

Run by

Stanford University

People needed

144

Starts

2010-11-01

Expected to finish

2014-05-01

Last updated by the study team

2015-06-08

Who can join

Age: 0 and older, up to 18. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Less than 18 years old, undergoing cardiac surgery with bypass
• neonates must be at least 36 weeks gestational age

You may not qualify if…

• History of arrythmia or seizure, on extracorporeal membrane oxygenation (ECMO) support, already taking aminophylline/theophylline, liver failure, sepsis, on renal replacement therapy

Where it is running

• Lucile Packard Childrens' Hospital — Palo Alto, California, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.