Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
Completed · Not applicable
Conditions studied: Knee Osteoarthritis
In brief
The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.
Key facts
- Study ID
- NCT01245283
- Run by
- University of Florida
- People needed
- 90
- Starts
- 2010-11-01
- Expected to finish
- 2013-06-01
- Last updated by the study team
- 2014-12-05
Who can join
Age: 60 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Osteoarthritis (OA) of the knee for >6 months
- moderate to severe pain immediately following a 50-foot walk
- knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
- bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
- willing and able to participate in regular exercise for four months
- free from musculoskeletal limitations that would preclude resistance exercise participation
- free of abnormal cardiovascular responses during the screening graded maximal walk test
You may not qualify if…
- unable to walk
- regular resistance exercise training (>3X week) within the past 6 months
- specific low back pain or acute back injury
- spinal stenosis that precludes walking one block due to neurogenic claudication
- any major injury to either knee within the prior 12 months
- any surgery to either knee within the last 12 months
- lumbar radiculopathy
- vascular claudication
- significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
- have had corticosteroid or viscosupplement injections within three months of study participation
- have added new over the counter or prescription pain medication within two months of study participation
Where it is running
- UF&Shands Orthopaedics and Sports Medicine Institute — Gainesville, Florida, United States
Full record on ClinicalTrials.gov
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