Neuroimaging the Impact of Treatment on Neural Substrates of Trust in Post-Traumatic Stress Disorder (PTSD)

Completed · Not applicable

Conditions studied: Stress Disorders, Post Traumatic, Trust

In brief

Traumatic experiences can have a profound negative effect on the lives and well-being of both the people who experience them and their loved ones. For those who experience post-traumatic stress disorder (PTSD), their interpersonal difficulties and social support further impact the success of treatment such that interpersonal difficulties are associated with mistrust and predict poor treatment outcome. In this proposal, the investigators use functional neuroimaging to understand the neurobiology of trust and mistrust in people with PTSD and to learn more about how successful treatment can improve trust and social functioning.

Key facts

Study ID

NCT01244477

Run by

VA Office of Research and Development

People needed

61

Starts

2011-05-16

Expected to finish

2018-06-30

Last updated by the study team

2019-06-27

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Meet criteria for PTSD on the Clinician Administered PTSD Scale (CAPS)
• Priority will be given to Veterans aged 18-50 who have had an onset of symptoms in the past 10 years and are Veterans of Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF)
• Have been referred for placement in CPT treatment by a clinician in the Trauma Recovery Program at the Michael E DeBakey VA Medical Center (MEDVAMC) or an eligible Veteran who contacts study staff.
• Are able to see the computer display clearly with or without magnetic Resonance imaging (MRI)-compatible corrective lenses
• Are free from current non-psychiatric medical problems impacting cognitive functioning.
• Are cleared to participate by a treating MEDVAMC clinician
• Are able to participate in functional MRI (fMRI)

You may not qualify if…

• Meet Diagnostic and Statistical Manual-IV (DSM-IV)criteria for drug or alcohol abuse in the past 30 days
• History of moderate to severe traumatic brain injury based on any of the following:
• (i) Glasgow Coma Score < 13
• (ii)alteration of consciousness > 24 hours; loss of consciousness,30 minutes
• Presence of contraindications to MRI, including but not limited to:
• claustrophobia
• pacemaker
• metal in eyes
• other implants
• Current neurological or general medical conditions known to impact cognitive and/or emotional functioning, including but limited to:
• epilepsy
• Parkinson's disease
• Huntington's disease
• Alzheimer's disease
• stroke
• chemotherapy for cancer
• Acute psychological instability as assessed by a Michael E DeBakey VA Medical Center (MEDVAMC) clinician or study staff
• Concurrent diagnosis of:
• schizophrenia
• schizoaffective disorder
• delusional disorder
• organic psychosis
• and subjects taking antipsychotic medication

Where it is running

• Michael E. DeBakey VA Medical Center, Houston, TX — Houston, Texas, United States

Full record on ClinicalTrials.gov

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