Brain Activation During Accommodation to Painful Stimulation With FMRI

Completed

Conditions studied: Pain

In brief

Blood oxygen level dependant (BOLD) functional magnetic resonance imaging (FMRI) investigations of pain have provided substantial insight into the workings of the human brain. To date, however, the vast majority of studies have dealt with short painful stimulations. This work will expand the investigators knowledge of how longer stimulations are processed by comparing the activation pattern from a two minute painful stimulation with that of an 30-second painful stimulus. The investigators hypothesis that accommodation to the longer stimulation will be evident by either decreases in signal intensity in brain areas known to process pain, or by increasing activity in brain areas thought to be responsible for the modulation of painful perception.

Key facts

Study ID

NCT01242540

Run by

University of Pittsburgh

People needed

15

Starts

2010-11-01

Expected to finish

2016-10-01

Last updated by the study team

2017-06-26

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Age 18 to 50
• Right-handed
• Male or female
• Healthy individuals not taking any medication.

You may not qualify if…

• Pregnancy
• Diagnosed with any treated or untreated medical or neurological conditions
• Using any prescription drugs, including antidepressants, pain medications, sedative medications, blood pressure medications, seizure medications, or antipsychotics. Oral contraceptives are permitted
• Using any over-the-counter medications including aspirin, Tylenol, or herbal supplements
• Using any illicit substances
• Contraindications to magnetic resonance imaging.

Where it is running

• University of Pittsburgh — Pittsburgh, Pennsylvania, United States

Full record on ClinicalTrials.gov

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