Evaluation of Long-term Safety and Effectiveness of Fostamatinib in the Treatment of Rheumatoid Arthritis (RA)

Stopped early · Phase 3

Conditions studied: Rheumatoid Arthritis

In brief

The purpose of this study is to evaluate the long term safety and tolerability of fostamatinib in patients with rheumatoid arthritis (RA).

Key facts

Study ID

NCT01242514

Run by

AstraZeneca

People needed

1917

Starts

2011-01-01

Expected to finish

2015-01-01

Last updated by the study team

2014-04-04

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients who have successfully completed a qualifying study (D4300C00001, D4300C00002, D4300C00003 or D4300C00004) with fostamatinib
• Patients who have participated in a qualifying study and who have been classified as non-responders due to pre-defined lack of efficacy at Week 12 (D4300C00001, D4300C00002, D4300C00003).

You may not qualify if…

• Premature withdrawal from the qualifying study (D4300C00001, D4300C00002, D4300C00003 and D4300C00004)
• Females who are pregnant or breast feeding
• Poorly controlled hypertension
• Significant liver function test abnormalities or physical symptoms of hepatotoxicity
• Significant infection
• Gastrointestinal intolerance
• Cancer

Where it is running

• Research Site — Birmingham, Alabama, United States
• Research Site — Huntsville, Alabama, United States
• Research Site — Tuscaloosa, Alabama, United States
• Research Site — Glendale, Arizona, United States
• Research Site — Mesa, Arizona, United States
• Research Site — Phoenix, Arizona, United States
• Research Site — Scottsdale, Arizona, United States
• Research Site — Tucson, Arizona, United States
• Research Site — Hot Springs, Arkansas, United States
• Research Site — Anaheim, California, United States
• Research Site — Fountain Valley, California, United States
• Research Site — Huntington Beach, California, United States
• Research Site — La Jolla, California, United States
• Research Site — Long Beach, California, United States
• Research Site — Palo Alto, California, United States
• Research Site — Roseville, California, United States
• Research Site — Santa Maria, California, United States
• Research Site — Santa Monica, California, United States
• Research Site — Torrance, California, United States
• Research Site — Upland, California, United States
• Research Site — Colorado Springs, Colorado, United States
• Research Site — Bridgeport, Connecticut, United States
• Research Site — Danbury, Connecticut, United States
• Research Site — Trumbull, Connecticut, United States
• Research Site — Anniston, Alabama, United States

Full record on ClinicalTrials.gov

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