One-Time DNA Study for Vasculitis

Recruiting now

Conditions studied: Eosinophilic Granulomatosis With Polyangiitis (Churg-Strauss), Giant Cell Arteritis, Granulomatosis With Polyangiitis (Wegener's), Microscopic Polyangiitis, Polyarteritis Nodosa, Takayasu's Arteritis

In brief

The purpose of this study is to identify genes that increase the risk of developing vasculitis, a group of severe diseases that feature inflammation of blood vessels. Results of these studies will provide vasculitis researchers with insight into the causes of these diseases and generate new ideas for diagnostic tests and therapies, and will be of great interest to the larger communities of researchers investigating vasculitis and other autoimmune, inflammatory, and vascular diseases.

Key facts

Study ID

NCT01241305

Run by

University of Pennsylvania

People needed

1000

Starts

2010-10-01

Expected to finish

2028-08-01

Last updated by the study team

2026-01-22

Who can join

Age: 7 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnostic criteria for Giant Cell Arteritis Age at disease onset >50 years (required)
• New onset or new type of localized pain in the head
• Temporal artery abnormality (i.e. temporal artery tenderness to palpation or decreased pulsation, unrelated to arteriosclerosis of cervical arteries)
• ESR of >40mm in the first hour by the Westergren method
• Abnormal artery biopsy (i.e. temporal artery biopsy showing vasculitis characterized by a predominance of mononuclear cell infiltration or granulomatous inflammation, usually with multinucleated giant cells)
• Large Vessel Vasculitis (LVV) by angiogram or biopsy not explained by something else
• Inclusion Criteria:
• Diagnostic criteria for Takayasu's Arteritis
• Age at disease onset <50 years
• Claudication of extremities
• Decreased brachial artery pulse (one or both arteries)
• Blood pressure difference of >10mm Hg between the arms
• Bruit over subclavian arteries or aorta
• Arteriogram abnormalities compatible with TAK (includes conventional dye angiography or MR angiography or CT angiography)
• Inclusion Criteria:
• Diagnostic criteria for Polyarteritis Nodosa Major criteria (not explained by other causes) felt by investigator to be due to vasculitis
• Arteriographic abnormality
• Presence of granulocyte or mixed leukocyte infiltrate in an arterial wall on biopsy
• Mononeuropathy or polyneuropathy
• Minor criteria (not explained by other causes) felt by investigator to be due to vasculitis
• Weight loss > 4 kg
• Livedo reticularis, cutaneous ulcerations, or skin nodules
• Testicular pain or tenderness
• Myalgias
• Diastolic blood pressure > 90 mm Hg

Where it is running

• University of Pennsylvania — Philadelphia, Pennsylvania, United States (enrolling)
• St. Joseph's Healthcare — Hamilton, Ontario, Canada (enrolling)
• Mount Sinai Hospital — Toronto, Ontario, Canada (enrolling)
• Northwestern University — Chicago, Illinois, United States (enrolling)
• Mayo Clinic — Rochester, Minnesota, United States
• Hospital for Special Surgery — New York, New York, United States
• Cleveland Clinic — Cleveland, Ohio, United States
• University of Pittsburgh — Pittsburgh, Pennsylvania, United States
• University of Utah — Salt Lake City, Utah, United States
• Cedars-Sinai Medical Center — Los Angeles, California, United States
• Istanbul University — Istanbul, Fatih, Turkey (Türkiye)
• University of California, San Francisco — San Francisco, California, United States
• University of Kansas Medical Center — Kansas City, Kansas, United States
• University of Michigan — Ann Arbor, Michigan, United States

Full record on ClinicalTrials.gov

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