Iron Mediated Vascular Disease in Sickle Cell Anemia Patients

Completed

Conditions studied: Sickle Cell Disease

In brief

The purpose of this research study is to determine the frequency and severity of iron overload in patients with Sickle Cell Anemia and its relationship to blood vessel function. The investigators hypothesize that intermittent transfusions that these patients receive during hospitalizations produces significant iron overload and impairs blood vessel relaxation.

Key facts

Study ID

NCT01239901

Run by

Children's Hospital Los Angeles

People needed

150

Starts

2009-12-01

Expected to finish

2018-10-01

Last updated by the study team

2019-01-10

Who can join

Age: 13 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Age > 13 years
• Documented diagnosis of sickle cell anemia (SS, SC, Sß0, Sß+)
• Transfused no more than 8 times in a year.

You may not qualify if…

• Cardiac pacemaker, implantable neurostimulator or other MRI incompatible device.
• History of extreme claustrophobia in MRI machine or other reason for inability to do MRI without sedation.
• Inability to be positioned on the MRI table for sufficient time to complete the MRI exams.
• Any medical or psychological condition that, in the opinion of the local investigator, would make it unsafe or ill-advised for the subject to participate.
• Currently not receiving chronic transfusion therapy, defined as greater than 8 transfusions per year.

Where it is running

• Children's Hospital Los Angeles — Los Angeles, California, United States

Full record on ClinicalTrials.gov

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