Peroxisomal Defects and Familial Risk for Bipolar Disorder

Completed

Conditions studied: Bipolar Disorder, Mania

In brief

The purpose of this study is to screen for peroxisome defects in child and adolescent offspring of Bipolar Disorder I (BD-I) parents at different stages of risk for transitioning to mania and following the onset of mania. Prediction 1: Youth with an elevated risk for developing BD-I and first-episode manic patients will exhibit graded deficits in measures of peroxisomal function compared with healthy controls. Prediction 2: Indices of peroxisomal function will be correlated with Red Blood Cells Docosahexaenoic acid (DHA) composition. Prediction 3: Graded deficits in measures of peroxisomal function will be inversely correlated with manic and depression symptom severity scores.

Key facts

Study ID

NCT01237379

Run by

University of Cincinnati

People needed

80

Starts

2010-10-01

Expected to finish

2013-10-01

Last updated by the study team

2014-12-23

Who can join

Age: 10 and older, up to 18. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• 10 -18 year old males \& females
• Based on currently enrolled study.

You may not qualify if…

• Based on currently enrolled study.

Where it is running

• University of Cincinnati — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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