The Effect of Avocado on Cardiovascular Disease (CVD) Risk Factors
Completed · Not applicable
Conditions studied: Cardiovascular Disease, Hyperlipidemia
In brief
The investigators propose to evaluate the effects of avocado consumption (by incorporating 1 unit of fruit per day into a healthy diet) on multiple cardiovascular disease (CVD) risk factors. The investigators will compare chronic consumption of a moderate fat blood cholesterol-lowering diet incorporating one avocado per day versus a blood cholesterol-lowering Lower-Fat diet on established CVD risk factors including lipids and lipoproteins, and blood pressure (BP). The investigators also will evaluate the effects of an avocado diet on several emerging CVD risk factors. To elucidate the specific benefits of avocado and its accompanying bioactives on the aforementioned risk factors, the investigators will compare the avocado diet with a diet that has the same macronutrient profile (but without the avocado).
Key facts
- Study ID
- NCT01235832
- Run by
- Penn State University
- People needed
- 54
- Starts
- 2010-11-01
- Expected to finish
- 2013-02-01
- Last updated by the study team
- 2023-08-21
Who can join
Age: 21 and older, up to 70. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- healthy non-smoking
- overweight (BMI 25-35 kg/m2) men and women
- LDL-C between the25-90th percentile from NHANES: 105-194mg/dL for males; 98-190mg/dL for females)
You may not qualify if…
- BP >140/90 mmHg;
- A history of myocardial infarction, stroke, diabetes mellitus, liver disease, kidney disease, and thyroid disease (unless controlled on medication);
- Lactation, pregnancy, or desire to become pregnant during the study;
- Cholesterol-lowering medication use;
- Intake of putative cholesterol-lowering supplements (psyllium, fish oil capsules, soy lecithin, niacin, fiber, flax, and phytoestrogens, stanol/sterol supplemented foods);
- Vegetarianism;
- Nut allergies (Other food allergies were reviewed on a case-by-case basis);
- Refusal to discontinue nutritional supplements, herbs or vitamins
Where it is running
- Penn State University — University Park, Pennsylvania, United States
Full record on ClinicalTrials.gov
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