Tolerance to Target Doses of Thiazides in Actual Practice: A Feasibility Study

Completed · Phase 4

Conditions studied: Hypertension

In brief

This is a pilot study of a method to compare common, FDA-approved drugs in a clinic. Instead of putting single patients into one of two drug groups, the investigators will assign the doctors who prescribe these drugs for high blood pressure into two groups. One group of doctors has agreed to prescribe mostly ("favor") one drug, chlorthalidone, if that drug would be a good choice for a patient. The other group has agreed to prescribe mostly hydrochlorothiazide. For both groups, they will try to use the doses that were shown to be protective in other trials. If the doctors mostly prescribe the drug they agreed to favor, the investigators will be able to compare outcomes, like heart attacks, in the two groups.

Key facts

Study ID

NCT01235377

Run by

VA Pharmacy Benefits Management Strategic Healthcare Group

People needed

20

Starts

2011-09-01

Expected to finish

2014-02-01

Last updated by the study team

2014-11-25

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• VA prescribers of thiazides for hypertension

You may not qualify if…

• at non-participating VA sites

Where it is running

• Edward Hines, Jr. VA Hospital — Hines, Illinois, United States
• Charles George VAMC — Asheville, North Carolina, United States
• Wilkes-Barre VA Medical Center — Wilkes-Barre, Pennsylvania, United States
• WJB Dorn VA Medical Center — Columbia, South Carolina, United States
• WJB Dorn VAMC/Columbia Orangeburg VA Outpatient Clinic — Orangeburg, South Carolina, United States

Full record on ClinicalTrials.gov

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