Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors

Stopped early · Phase 2

Conditions studied: Hypertension, Unspecified Adult Solid Tumor, Protocol Specific

In brief

RATIONALE: Benazepril hydrochloride, lisinopril, ramipril, and losartan potassium may help lower blood pressure. PURPOSE: This phase II trial is studying how well benazepril hydrochloride, lisinopril, ramipril, or losartan potassium works in treating hypertension in patients with solid tumors.

Key facts

Study ID

NCT01234922

Run by

Wake Forest University Health Sciences

People needed

6

Starts

2011-02-01

Expected to finish

2014-04-01

Last updated by the study team

2018-08-28

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Patients must have histologically or cytologically confirmed solid tumor malignancy AND hypertension, defined as a systolic pressure > 130 OR a diastolic pressure > 80
• Patients cannot be on active chemotherapy or radiation therapy; start of treatment with ACE-I or ARB must occur at least four weeks after the last dose of chemotherapy or radiation therapy
• Creatinine < 2.5
• Potassium < ULN
• Ability to understand and the willingness to sign a written informed consent document
• HIV positive patients are eligible to participate in this study

You may not qualify if…

• Patients who are pregnant or nursing due to significant risk to the fetus/infant
• Patients who are unable to take oral medications
• Patients who are currently taking an ACE-Inhibitor or ARB

Where it is running

• Wake Forest University Health Sciences — Winston-Salem, North Carolina, United States

Full record on ClinicalTrials.gov

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