Cooperation of Insulin and GLP-1 on Myocardial Glucose Uptake

Completed · Not applicable

Conditions studied: Type 2 Diabetes

In brief

27 Type 2 diabetic subjects (HbA1c 7.5 - 9.5%) currently treated with diet and exercise alone or with oral antidiabetic agents will be randomly assigned to one of three treatment groups: insulin detemir, liraglutide, or liraglutide plus detemir (9 subjects per group), on a background of metformin 2000 mg per day. After 3 months' treatment, PET measurements of myocardial fuel selection will take place, under fasting conditions in the morning following that day's treatment injection(s).

Key facts

Study ID

NCT01232946

Run by

Indiana University

People needed

30

Starts

2012-01-01

Expected to finish

2017-09-08

Last updated by the study team

2019-08-07

Who can join

Age: 18 and older, up to 50. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Type 2 diabetic
• 18-50 years
• BMI > 25kg/m2
• HbA1c 7.0-10.0%
• Treated with up to 2 oral agents

You may not qualify if…

• Chronic illness or infection (other than diabetes mellitus)
• Known coronary artery disease, structural heart disease or abnormal ECG on screen.
• Treatment with >2 antihypertensive agents or blood pressure >140/95 on two occasions during screening
• History of claustrophobia, musculoskeletal or other factors which would result in an inability to comfortably remain within the PET scanner gantry for the duration of the imaging protocol.
• Occupational, investigational or other known radiation exposure which together with the planned radiologic studies, will result in greater than 500 mrem total exposure in a 12 month period.
• Current pregnancy
• Treatment with GLP-1 agonist or DPP4 inhibitor within the past 6 months
• Known intolerance to GLP-1 agonist
• Personal history of pancreatitis, personal or family history of medullary thyroid carcinoma, or other contraindications to liraglutide treatment.
• Recognized microvascular complications (neuropathy, nephropathy, retinopathy).

Where it is running

• Indiana Clinical Research Center — Indianapolis, Indiana, United States

Full record on ClinicalTrials.gov

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