A Pilot Trial of Acute N-Acetylcysteine Effects on Working Memory and Other Cognitive Functions in Schizophrenia

Completed · Not applicable · Has a placebo group

Conditions studied: Schizophrenia

In brief

The purpose of this study is to evaluate the effects of the amino acid supplement N-Acetylcysteine versus placebo on working memory and other cognitive functions in persons with a diagnosis of schizophrenia.

Key facts

Study ID

NCT01232790

Run by

Yale University

People needed

28

Starts

2010-02-01

Expected to finish

2011-11-01

Last updated by the study team

2015-12-01

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Subjects will be between 18-60
• Meet Diagnostic and Statistical Manual-IV (DSM) criteria for schizophrenia
• Be on a stable dose of antipsychotic medication for at least 1 month
• Be deemed clinically stable for 3 months by the regular clinical staff

You may not qualify if…

• Current substance or alcohol abuse
• Pregnancy
• Clozapine treatment
• Known sensitivity to sulphur containing compounds
• Previous diagnosis of mental retardation
• Nitroglycerin use
• Asthma diagnosis, verified and treated by a primary care doctor
• Use of any other medication that may interact with the study medication

Where it is running

• Connecticut Mental Health Center — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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