A Study of Brain Receptor Occupancy in Healthy Subjects

Completed · Phase 1

Conditions studied: Alcohol Dependence

In brief

To measure the occupancy of brain kappa opioid receptors after single oral doses of LY2456302.

Key facts

Study ID

NCT01232439

Run by

Eli Lilly and Company

People needed

13

Starts

2010-12-01

Expected to finish

2011-04-01

Last updated by the study team

2011-05-09

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Healthy male or female
• Have clinical laboratory tests within normal reference ranges
• Have arterial and venous access sufficient to allow blood sampling

You may not qualify if…

• Currently enrolled in, or discontinued within the last 30 days from a clinical trial
• History of severe allergies or multiple adverse drug reactions
• Have an abnormal ECG at screening visit
• Have abnormal sitting blood pressure
• Have an increased risk of seizures
• Current suicidal ideation
• Positive test for HIV, hepatitis C, or hepatitis B
• Women who are breast feeding
• Smoke more than 10 cigarettes per day, or equivalent
• Drink more than 5 cups of coffee per day, or equivalent
• Have a history of head injury
• Unable to undergo a MRI
• Suffer from claustrophobia

Where it is running

• For additional information regarding investigative sites for this trial, contact 1-877-CTLILLY (1-877-285-4559, 1-317-615-4559) Mon - Fri from 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST), or speak with your personal physician. — New Haven, Connecticut, United States

Full record on ClinicalTrials.gov

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