Study to Evaluate Esmolol (Brevibloc) to Manage Cardiac Function in Patients With Subarachnoid Hemorrhage
Withdrawn before enrolling · Not applicable
Conditions studied: Subarachnoid Hemorrhage
In brief
The purpose of this study is to evaluate the clinical effect of esmolol treatment on cardiac function and electrophysiology; to assess the effects of esmolol treatment on serum adrenergic and cardiac biomarkers; to explore the safety of esmolol treatment shortly after subarachnoid hemorrhage (SAH). Patients will be followed for a maximum of 1 month after the index SAH. The primary outcome will be change in systolic function - ejection fraction by Simpson's rule (baseline versus Day 7 +/- 2 after SAH).
Key facts
- Study ID
- NCT01232400
- Run by
- University of Michigan
- People needed
- 0
- Starts
- 2014-07-01
- Expected to finish
- 2016-08-01
- Last updated by the study team
- 2015-01-08
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- Subarachnoid hemorrhage presumed to be the result of ruptured aneurysm
- Age 18 years old or greater
- Able to enroll within 24 hours of onset of symptoms
- Systolic blood pressure over 140 mm Hg OR administration of antihypertensives after presentation
You may not qualify if…
- Withdrawal of life support imminent (within six hours)
- Known heart failure or cardiomyopathy AND ejection fraction 35% or below
- Prisoner or pregnant female
- Ongoing vasopressor administration to maintain SBP, or clinical suspicion of left ventricular failure
- Clinically important arrhythmias (history of cardiac arrest or ventricular arrhythmias), conduction abnormalities (Mobitz Type 2, 3rd degree AV block, or symptomatic Mobitz 1 without pacemaker), clinical cardiogenic shock, or overt clinical heart failure
- Active bronchospastic disease (ongoing bronchospasm after SAH presentation or current treatment with oral corticosteroids for asthma or obstructive lung disease)
- End stage renal disease
Where it is running
- University of Michigan Health System — Ann Arbor, Michigan, United States
Full record on ClinicalTrials.gov
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