Efficacy of Topical Capsaicin Cream for Stable Angina

Stopped early · Phase 3 · Has a placebo group

Conditions studied: Stable Angina

In brief

The purpose of this study is to test the hypothesis that application of topical capsaicin in patients with stable angina will result in improved exercise tolerance and reduced cardiac ischemia.

Key facts

Study ID

NCT01231750

Run by

Neal Weintraub

People needed

7

Starts

2010-10-01

Expected to finish

2012-03-01

Last updated by the study team

2015-06-25

Who can join

Age: 18 and older, up to 80. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• > or = 3 month history of chronic, stable, angina triggered by physical effort or mental/emotional stress
• documented stress-induced ST depression, reversible perfusion imaging, or wall motion abnormality or CAD >50%
• Canadian Cardiovascular (CV) Class I-III
• Receiving medical therapy for > or = 2 months
• Ability to perform Bruce Protocol treadmill test
• non-pregnant female

You may not qualify if…

• unstable angina
• revasc within 2 months
• Myocardial infarction (MI) within 2 months
• congestive heart failure (CHF) hospitalization within 2 months
• New York Heart Association (NYHA) class III or IV
• left ventricular ejection fraction (LVEF) < 25%
• abnormal ECG; Acute changes on ECG
• Currently receiving treatment with investigational drugs/devices
• Uncontrolled hypertension
• contraindication to exercise stress testing
• allergy to red peppers or capsaicin
• skin deformity, scar, or rash at application site
• abdominal surgery within 3 months

Where it is running

• University of Cincinnati Physicians, Inc — Cincinnati, Ohio, United States

Full record on ClinicalTrials.gov

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