QUILT-2.014: Gemcitabine and AMG 479 in Metastatic Adenocarcinoma of the Pancreas

Completed · Phase 3 · Has a placebo group

Conditions studied: Adenocarcinoma of the Pancreas, Advanced Solid Tumors, Cancer, Cancer of Pancreas, Cancer of the Pancreas, Metastases, Metastatic Cancer, Metastatic Pancreatic Cancer, Pancreas Cancer, Pancreatic Cancer, Bone Metastases, Endocrine Cancer, Oncology, Oncology Patients, Solid Tumors, Advanced Malignancy

In brief

AMG 479 is an investigational fully human monoclonal antibody that targets type 1 insulin-like growth factor receptor (IGF-1R). Signaling through IGF-1R plays an important role in the regulation of cell growth and survival. The primary purpose of the study is to determine if AMG 479 and gemcitabine improves overall survival as compared to placebo and gemcitabine.

Key facts

Study ID

NCT01231347

Run by

NantCell, Inc.

People needed

800

Starts

2011-04-07

Expected to finish

2012-12-12

Last updated by the study team

2024-07-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Untreated metastatic adenocarcinoma of the pancreas
• Adequate hematologic, renal and liver function
• Eastern Cooperative Oncology Group (ECOG) 0 or 1

You may not qualify if…

• Prior chemotherapy or radiotherapy for pancreatic cancer
• Central nervous system metastases
• External biliary drain

Where it is running

• Research Site — La Jolla, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Los Angeles, California, United States
• Research Site — Rancho Mirage, California, United States
• Research Site — Redondo Beach, California, United States
• Research Site — Santa Maria, California, United States
• Research Site — Chicago, Illinois, United States
• Research Site — Harvey, Illinois, United States
• Research Site — Quincy, Illinois, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Boston, Massachusetts, United States
• Research Site — Detroit, Michigan, United States
• Research Site — Grand Rapids, Michigan, United States
• Research Site — Durham, North Carolina, United States
• Research Site — Bend, Oregon, United States
• Research Site — Providence, Rhode Island, United States
• Research Site — Providence, Rhode Island, United States
• Research Site — Charleston, South Carolina, United States
• Research Site — Knoxville, Tennessee, United States
• Research Site — Fort Worth, Texas, United States
• Research Site — Paris, Texas, United States
• Research Site — Abingdon, Virginia, United States
• Research Site — Spokane Valley, Washington, United States
• Research Site — Kogarah, New South Wales, Australia
• Research Site — Fullerton, California, United States

Full record on ClinicalTrials.gov

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