Uric Acid and the Endothelium in CKD

Completed · Not applicable · Has a placebo group

Conditions studied: Kidney Disease

In brief

This study will test the hypothesis that uric acid impairs the function of vessels in patients with kidney disease

Key facts

Study ID

NCT01228903

Run by

University of Colorado, Denver

People needed

80

Starts

2010-10-01

Expected to finish

2016-09-01

Last updated by the study team

2017-06-28

Who can join

Age: 18 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Individuals with moderate chronic kidney disease (CKD stage III) with estimated glomerular filtration rates between 30-60 mL/min/ 1.73m2
• Elevated uric acid levels
• Age range: more than 18 years old
• Ability to give informed consent
• Albumin > 3.0 g/dL
• BMI < 40 kg/m2

You may not qualify if…

• Life expectancy < 1.0 years
• Expected to undergo living related kidney transplant in 6 months
• Pregnant, breast feeding, or unwilling to use adequate birth control
• History of severe liver disease
• History of severe congestive heart failure
• History of hospitalizations within 3 months
• Active infection, on antibiotics
• History of Warfarin Use or other medications that are contraindicated with allopurinol
• Uncontrolled hypertension
• History of acute gout on Allopurinol
• History of adverse reaction to Allopurinol
• Immunosuppressive therapy within the last 1 yr

Where it is running

• University of Colorado at Denver — Aurora, Colorado, United States

Full record on ClinicalTrials.gov

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