A Prospective Evaluation of Thromboelastography for Identifying Coagulopathy in Severely Injured Patients

Completed

Conditions studied: Coagulopathy

In brief

The purpose of this study is to evaluate the clinical utility of thrombelastography (TEG) to predict and identify trauma patients at increased risk of receiving blood transfusion, develop multiple organ failure and mortality. TEG has been proposed as a superior tool to rapidly diagnose and help guide resuscitation with blood products and preclinical data suggest that TEG is both more sensitive and specific than PT or PTT for coagulation abnormalities. Based on the preclinical work led by Dr. Holcomb, our hypothesis is that the Rapid TEG will help to identify these coagulopathic patients earlier, allow for rapid MT protocol activation, and assist in developing data driven blood product transfusion guidelines.

Key facts

Study ID

NCT01228058

Run by

The University of Texas Health Science Center, Houston

People needed

1450

Starts

2010-11-01

Expected to finish

2012-01-01

Last updated by the study team

2012-12-18

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Major trauma patients who require the highest level of trauma team activation at each site.
• Estimated age of 18 or higher
• Transfers less than 6 hours post-injury Exclusion Criteria: -Children less than 18 years of age.
• Burns > 20% of body surface area
• CPR pre-hospital
• Prisoners - defined as anyone directly admitted from a correctional facility

Where it is running

• University of California - San Francisco — San Francisco, California, United States
• Oregon Health and Science University — Portland, Oregon, United States
• Memorial Hermann Hospital - Texas Medical Center — Houston, Texas, United States

Full record on ClinicalTrials.gov

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