Quantitative Imaging and Proton Spectroscopy in Multiple Sclerosis

Stopped early · Not applicable

Conditions studied: Multiple Sclerosis

In brief

The primary purpose of this study is to detect changes in the brain that may be associated with multiple sclerosis. Results will be compared to age matched controls. Investigators will assess lesions by measuring T2 and T1 enhanced lesion volumes and magnetization transfer ratio histogram parameters (MTRHP) in patients with relapsing-remitting and secondary-progressive disease. This data will be correlated to total brain parenchymal volume as well as identifying the effect of MS lesions on the gray and white matter, volumetric disability, including Kurtzke Expanded Disability Status Scale (EDSS) and a specific battery of neuropsychological tests. Quantitative analysis of whole brain N-acetylaspartate (WBNAA), a reproducible measure of viable neuron number, using 1H MRS and compare the results to age-matched controls over duration of 5 years.

Key facts

Study ID

NCT01226654

Run by

NYU Langone Health

People needed

69

Starts

1991-08-01

Expected to finish

2016-04-01

Last updated by the study team

2017-08-01

Who can join

Age: 7 and older, up to 110. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Patients with known MS diagnosis
• Age 7-110 years
• Males or females

You may not qualify if…

• Medically unstable
• Artificial implants in the body
• Pregnant
• Normal Controls

Where it is running

• NYU Langone Medical Center — New York, New York, United States

Full record on ClinicalTrials.gov

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