Safety and Efficacy of Delayed Manipulation After Xiaflex Treatment in Subjects With Dupuytren's Contracture

Stopped early · Phase 4

Conditions studied: Dupuytren's Disease

In brief

The purpose of this study is to determine if of manipulation of digits following collagenase injection for treatment of Dupuytren's contracture is effected by the amount of time between injection and manipulation.

Key facts

Study ID

NCT01226121

Run by

Indiana Hand to Shoulder Center

People needed

37

Starts

2010-12-01

Expected to finish

2012-12-01

Last updated by the study team

2014-06-16

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Adult subjects (> 18 years) of either gender with an metacarpophalangeal joint contracture and a palpable cord of > 20 degrees of a digit (excluding the thumb) due to Dupuytren's contracture

You may not qualify if…

• Any subject who has had prior surgical, percutaneous needle aponeurotomy or Xiaflex treatment for Dupuytren's contracture.
• Any subject using anti-coagulant therapy other than low dose aspirin (up to 150mg/day).
• Any subject in the opinion of the MD investigators with chronic, severe or terminal medical illness which would make them unsuitable for study participation.
• Any subject with known allergy to Xiaflex (Clostridial collagenase).
• Any subject who cannot conform to the study visit schedule

Where it is running

• Indiana Hand to Shoulder Center — Indianaplis, Indiana, United States
• Stony Brook University — Stony Brook, New York, United States

Full record on ClinicalTrials.gov

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