Study of Sodium Bicarbonate in Kidney Transplant Recipients

Completed · Early Phase 1

Conditions studied: Kidney Transplantation

In brief

The purpose of this study is to compare the effect of sodium bicarbonate versus no sodium bicarbonate treatment on urinary ammonia levels and urinary transforming growth factor-beta1 (TGF-beta1) excretion in renal transplant patients with low-to-normal serum bicarbonate levels (20 - 28 mmol/L).

Key facts

Study ID

NCT01225796

Run by

University of Utah

People needed

29

Starts

2010-11-01

Expected to finish

2012-11-01

Last updated by the study team

2016-04-06

Who can join

Age: 21 and older, up to 75. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Renal transplant recipients
• Age 21-75 years
• Six months since the time of the most recent transplant
• Serum bicarbonate 20-28mM on the two most recent serum measures with the last six months
• Stable creatinine

You may not qualify if…

• Systolic blood pressure > 140mmHg
• Diastolic blood pressure > 90mmHg
• Known ejection fraction <50%
• Clinical diagnosis of heart failure
• Use of >3 antihypertensive agents
• > 1+ edema
• Use of alkali in the preceding 3 months
• History of noncompliance with clinic visits

Where it is running

• University of Utah — Salt Lake City, Utah, United States

Full record on ClinicalTrials.gov

Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.