Ceftriaxone in Non-neutropenic Fever

Completed

Conditions studied: Histiocytosis, Pediatric Patients With Cancer

In brief

This is a retrospective chart review of all patients cared for at Monroe Carell Jr. Children's Hospital at Vanderbilt including the following: * patients between 2007-2009 with malignancy, Langerhans cell histiocytosis (LCH) or hemophagocytic lymphohistiocytosis (HLH) and a central venous catheter who were under 23 years of age at time of diagnosis in order to ascertain the associated symptoms, management and outcome of all episodes of non-neutropenic fever. * to identify a subset of low-risk patients that can be safely managed without use of empiric antibiotics.

Key facts

Study ID

NCT01225718

Run by

Vanderbilt University Medical Center

People needed

463

Starts

2010-08-01

Expected to finish

2016-06-25

Last updated by the study team

2017-04-17

Who can join

Age: any, up to 22. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Diagnosed with malignancy, Langerhans cell histiocytosis,or hemophagocytic lymphohistiocytosis from 2007 through 2010
• Under 23 years at time of diagnosis of malignancy, Langerhans cell histiocytosis,or hemophagocytic lymphohistiocytosis
• Treated at Monroe Carell Jr. Children's Hospital at Vanderbilt for aforementioned diagnosis from 2007 through 2012
• While on immunosuppressive therapy with a central venous line in place had at least one documented episode of fever (defined as ≥ 38.0°Celsius orally for over 30 minutes or ≥ 38.3°Celsius orally x1).

You may not qualify if…

• Does not meet all inclusion criteria as stated above

Where it is running

• Monroe Carrell Jr. Children's Hospital at Vanderbilt — Nashville, Tennessee, United States

Full record on ClinicalTrials.gov

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