Study of BMS-754807 Combined With Letrozole or BMS-754807 Alone in Patients With Hormone Receptor-Positive Breast Cancer and Resistance to Non-Steroidal Aromatase Inhibitors
Stopped early · Phase 2
Conditions studied: Breast Cancer
In brief
The purpose of this study is to evaluate oral doses of BMS-754807 in combination with letrozole or BMS-754807 alone are safe and efficacious in locally advanced or metastatic hormone receptor positive breast cancer subjects who have progressed with prior non-steroidal aromatase inhibitor treatment.
Key facts
- Study ID
- NCT01225172
- Run by
- Bristol-Myers Squibb
- People needed
- 77
- Starts
- 2010-12-31
- Expected to finish
- 2014-11-30
- Last updated by the study team
- 2020-08-11
Who can join
Age: 18 and older. Sex: female. Healthy volunteers: not accepted.
You may qualify if…
- Postmenopausal women with hormone receptor-positive and HER-2 negative breast cancer
- Disease progression following non-steroidal aromatase inhibitor treatment
You may not qualify if…
- Known symptomatic brain metastasis
- Medical condition requiring chronic steroids
- History of Type 1 or 2 Diabetes
- Uncontrolled or significant cardiovascular (CV) disease
- Concomitant second malignancies
Where it is running
- Univ Of Al At Birmingham — Birmingham, Alabama, United States
- Mayo Clinic Arizona — Scottsdale, Arizona, United States
- Sharp Clinical Oncology Research — San Diego, California, United States
- Mayo Clinic — Jacksonville, Florida, United States
- University Of Chicago Medical Center — Chicago, Illinois, United States
- Illinois Cancercare, Pc — Peoria, Illinois, United States
- Indiana University Health Goshen Center For Cancer Care — Goshen, Indiana, United States
- Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins — Baltimore, Maryland, United States
- Sidney Kimmel Comprehensive Cancer Center At Johns Hopkins — Baltimore, Maryland, United States
- Oncology Care Associates, P.A. — Wheaton, Maryland, United States
- Masonic Cancer Ctr, University Of Minnesota — Minneapolis, Minnesota, United States
- Mayo Clinic — Rochester, Minnesota, United States
- Unv. Of Nc At Chapel Hill — Chapel Hill, North Carolina, United States
- Unv. Of Nc At Chapel Hill — Chapel Hill, North Carolina, United States
- Presbyterian Hospital Cancer Research — Charlotte, North Carolina, United States
- Duke University Medical Center-Dept Of Medicine — Durham, North Carolina, United States
- Ut Md Anderson Can Ctr. — Houston, Texas, United States
- Ut Md Anderson Can Ctr. — Houston, Texas, United States
- University Of Virginia Health System — Charlottesville, Virginia, United States
- University Of Wisconsin — Madison, Wisconsin, United States
- University Of Wisconsin — Madison, Wisconsin, United States
Full record on ClinicalTrials.gov
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