Myeloid Suppressors in Inflammation

Completed

Conditions studied: Asthma

In brief

Myeloid-derived suppressor cells (MDSC) have been studied for their ability to suppress T cell responses in vivo and in vitro. As a result, MDSC can regulate cellular responses to chronic inflammatory conditions such as cancer, leading to the induction of tolerance and, ultimately, tumor escape from immune surveillance.

Key facts

Study ID

NCT01224223

Run by

University of South Florida

People needed

20

Starts

2010-10-01

Expected to finish

2012-01-01

Last updated by the study team

2012-06-28

Who can join

Age: 18 and older, up to 60. Sex: any. Healthy volunteers: not accepted.

You may not qualify if…

• Use of systemic corticosteroids within the previous two weeks.
• Pregnant and/or lactating females.
• Current tobacco use.
• Severe psychiatric illness.
• Current illicit substance abuse or dependence and/or abuse of alcohol.
• Current use of anti-microbial medications.
• Primary or secondary immunodeficiency.
• Any clinically significant uncontrolled medical condition that would put the patient's safety at risk.

Where it is running

• USF Asthma, Allergy and Immunology CRU — Tampa, Florida, United States

Full record on ClinicalTrials.gov

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