Studies of Disorders With Increased Susceptibility to Fungal Infections
Recruiting now
Conditions studied: Fungal Infections, Primary Immune Deficiencies
In brief
Background: \- Researchers are interested in studying disorders that make individuals more susceptible to fungal infections, specifically infections with the Candida yeast. These disorders are often related to problems with the immune system and may have genetic factors, which suggests that researchers should study not only the individual with the disorder, but also his or her first- and second-degree relatives (such as parents, siblings, children, and first cousins). To provide material for future research, individuals with immune disorders and their first- and second-degree relatives will be asked to provide blood and other samples for testing and comparison with samples taken from healthy volunteers with no history of immune disorders. Objectives: \- To collect blood and other biological samples to study immune disorders that make individuals more susceptible to fungal infections. Eligibility: * Individuals of any age who have abnormal immune function characterized by recurrent or unusual fungal infections, recurrent or chronic inflammation, or other types of immune dysfunction. * First- or second-degree genetically related family members (limited to mother, father, siblings, grandparents, children, aunts, uncles, and first cousins). * Healthy volunteers at least 18 years of age (for comparison purposes). Design: * Participants will provide blood samples and buccal (cells from the inside of the mouth near the cheek) samples. * Participants with immune disorders will also be asked to provide urine samples, saliva or mucosal samples, or skin tissue biopsies, and may also have imaging studies (such as x-rays) to collect information for research. * Samples may be collected at the National Institutes of Health or at other clinical locations for the samples to the sent to the National Institutes of Health. * No treatment will be provided as part of this protocol.
Key facts
- Study ID
- NCT01222741
- Run by
- National Institute of Allergy and Infectious Diseases (NIAID)
- People needed
- 850
- Starts
- 2011-01-07
- Last updated by the study team
- 2026-07-23
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: accepted.
You may not qualify if…
- Patients and Relatives
- In general, there are no strict exclusion criteria for these cohorts. However, the presence of certain types of acquired abnormalities of immunity solely due to HIV, chemotherapeutic agent(s), or an underlying malignancy could be grounds for possible exclusion for a patient or relative. In the opinion of the investigator, the presence of such disease processes may interfere with evaluation of a co-existing abnormality of immunity that is the subject of study under this protocol. Pregnant females will not be allowed to participate in any procedure that may be dangerous to the pregnancy or the fetus.
- Healthy volunteers
- An individual who meets any of the following criteria will be excluded from participation as a healthy volunteer in this study:
- Is receiving chemotherapeutic agent(s) or has an underlying malignancy.
- Is pregnant.
- Has a history of heart, lung, or kidney disease, or bleeding disorders.
- Has HIV or viral hepatitis (B or C), or history of viral hepatitis B or C since age 11.
Where it is running
- National Institutes of Health Clinical Center — Bethesda, Maryland, United States (enrolling)
Full record on ClinicalTrials.gov
Trial information comes from ClinicalTrials.gov and is refreshed daily. TrialsForMe does not provide medical care and does not run the studies it lists.