Delayed Cord Clamping in VLBW Infants

Completed · Phase 1/Phase 2

Conditions studied: Infant, Newborn, Infant, Low Birth Weight, Infant, Small for Gestational Age, Infant, Premature

In brief

This study tested the feasibility of conducting a randomized controlled trial to vary the timing that doctors clamp the umbilical cord after birth in extremely low birthweight infants. The study also tested whether delaying cord clamping by 30-35 seconds and holding the newborn approximately 10 inches below the birth canal would result in increased hematocrit at 4 hours of age.

Key facts

Study ID

NCT01222364

Run by

NICHD Neonatal Research Network

People needed

54

Starts

2000-06-01

Expected to finish

2000-12-01

Last updated by the study team

2026-06-17

Who can join

Age: any. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Infants born at participating centers at 24-27 weeks gestation
• Singletons
• Obstetrician approval for enrollment
• Parental consent

You may not qualify if…

• Prenatally diagnosed major congenital anomalies
• Intent to withhold or withdraw care
• Significant bleeding due to placenta previa or abruption

Where it is running

• University of Alabama — Birmingham, Alabama, United States
• Cincinnati Children's Medical Center — Cincinnati, Ohio, United States
• Case Western Reserve University, Rainbow Babies and Children's Hospital — Cleveland, Ohio, United States
• Brown University, Women & Infants Hospital of Rhode Island — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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