Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids

Completed · Phase 2 · Has a placebo group

Conditions studied: Hyperalgesia

In brief

This research study explores whether a beta-blocker (propranolol) can prevent a person from becoming more sensitive to pain after administration of an opioid (remifentanil). Beta blockers inhibit the sympathetic (fight or flight) response and are often used to treat angina and high blood pressure. In a previous study in human volunteers, the investigators demonstrated an increased sensitivity to pain after a 60-minute infusion of the opioid remifentanil. The goal of this study is to identify a possible inhibitor of this phenomenon.

Key facts

Study ID

NCT01222091

Run by

Stanford University

People needed

10

Starts

2009-02-01

Expected to finish

2011-06-01

Last updated by the study team

2018-06-15

Who can join

Age: 18 and older, up to 45. Sex: male. Healthy volunteers: accepted.

You may qualify if…

• Healthy men,
• Age between 18 and 45 years
• Normal weight (according to the table provided by Metropolitan Life Insurance).

You may not qualify if…

• Hypersensitivity to opioids or naloxone,
• History of addictive disease,
• Significant cardiac, respiratory, gastrointestinal, neurological, dermatological, and psychiatric diseases,
• Concurrent medication with an analgesic drug,
• Student and employees affiliated with our laboratory

Where it is running

• Stanford University School of Medicine — Stanford, California, United States

Full record on ClinicalTrials.gov

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