Effect of Ranolazine on Myocardial Perfusion Assessed by Serial Quantitative Exercise SPECT Imaging
Completed · Phase 4 · Has a placebo group
Conditions studied: Myocardial Perfusion Imaging, Myocardial Ischemia
In brief
This study enrolled participants with documented exercise-induced myocardial ischemia in order to evaluate whether ranolazine, when taken prior to exercise, can improve blood flow to the heart (myocardial perfusion), as assessed by exercise-induced myocardial perfusion defect size (PDS) and total perfusion deficit (TPD), using gated single photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). This was a 2-period crossover study. The last dose of each period must have been taken 3-4 hours prior to conduct of the exercise SPECT MPI. After the research exercise SPECT MPI was performed at the end of Period 1, participants discontinued the treatment they were randomized to for that period and began the other treatment in Period 2.
Key facts
- Study ID
- NCT01221272
- Run by
- Gilead Sciences
- People needed
- 81
- Starts
- 2010-09-01
- Expected to finish
- 2012-09-01
- Last updated by the study team
- 2014-09-03
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- University of Alabama at Birmingham — Birmingham, Alabama, United States
- Imperial Cardiac Center — Imperial, California, United States
- Clinical Trials Research — Lincoln, California, United States
- Mission Internal Medical Group — Mission Viejo, California, United States
- Central Coast Cardiology — Salinas, California, United States
- Alfieri Cardiology — Newark, Delaware, United States
- St. Luke's Cardiology Associates — Jacksonville, Florida, United States
- Cardiovascular Research Center of South Florida — Miami, Florida, United States
- Research One — Orlando, Florida, United States
- Cardiology Partners Clinical Research Institute — Wellington, Florida, United States
- Fox Valley Clinical Research Center, LLC — Aurora, Illinois, United States
- Research Integrity, LLC — Owensboro, Kentucky, United States
- Louisiana Heart Center — Covington, Louisiana, United States
- Louisiana Heart Center — Slidell, Louisiana, United States
- Androscroggin Cardiology Associates DBA Maine Research Associates — Auburn, Maine, United States
- Delmarva Heart Research Foundation, Inc — Salisbury, Maryland, United States
- Massachusetts General Hospital — Boston, Massachusetts, United States
- Cardiovascular Imaging Technologies — Kansas City, Missouri, United States
- Dr. Michael Sacher — Massapequa, New York, United States
- Columbia University Medical Center — New York, New York, United States
- Duke University Medical Center — Durham, North Carolina, United States
- Heritage Cardiology — Camp Hill, Pennsylvania, United States
- University of Pittsburgh Medical Center Cardiovascular Institute — Pittsburgh, Pennsylvania, United States
- Kore Cardiovascular Research — Jackson, Tennessee, United States
- East Texas Cardiology PA — Houston, Texas, United States
Full record on ClinicalTrials.gov
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