The Neural Correlates of Food Choice Decision-making in Obesity and Weight Loss

Status unconfirmed · Not applicable

Conditions studied: Obesity, Weight Loss, Weight Control

In brief

This study is designed to determine whether obese, normal weight, and successful weight loss maintainers differ in their food choice decision-making and/or executive function, and whether participation in a behavioral weight loss program leads to neural and/or behavioral changes. The investigators will examine behavioral performance on several tasks involving decision-making and self-control in conjunction with brain imaging data acquired during a food-choice decision-making task. Participants enrolled in the behavioral weight loss program will also be assessed following the treatment.

Key facts

Study ID

NCT01218503

Run by

The Miriam Hospital

People needed

90

Starts

2010-03-01

Expected to finish

2016-10-01

Last updated by the study team

2013-07-29

Who can join

Age: 35 and older, up to 55. Sex: female. Healthy volunteers: accepted.

You may qualify if…

• women, ages 35-55, who are either currently obese (BMI = 30-40 kg/m2), always normal weight (lifetime BMI < 25, NW) or successful weight loss maintainers who have lost 10% of their body weight and maintained that loss for at least 1 year (lifetime maximum BMI = 30-40 kg/m2)

You may not qualify if…

• weight loss medications, binge eating, standard MRI contraindications (e.g., metal implants, claustrophobia, pregnancy), left-handedness, food allergies, neurological or psychiatric conditions, including but not limited to schizophrenia, bipolar disorder, epilepsy, stroke and traumatic brain injury with loss of consciousness, and, among obese participants, inability to participate at two time points and lack of interest in participating in a behavioral weight loss trial
• serious current physical disease (e.g., heart disease and cancer) for which physician supervision of diet and exercise prescription is needed, physical problems that limit the ability to exercise, participation in a weight loss program in the last 2 months and intention to become pregnant in the next 6 months

Where it is running

• Weight Control & Diabetes Research Center — Providence, Rhode Island, United States (enrolling)
• Weight Control & Diabetes Research Center — Providence, Rhode Island, United States

Full record on ClinicalTrials.gov

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