Safety and Efficacy of Positron Emission Tomography (PET) Imaging With MNI-558

Completed · Early Phase 1

Conditions studied: Alzheimer Disease

In brief

This research will look at how the brain may change in people with Alzheimer disease (AD). The purpose of this research is to find out whether changes in the brain in people with Alzheimer disease can be detected using a brain imaging test. Most people with Alzheimer disease have changes in the brain that result in deposits of a protein called beta-amyloid. In this study, the investigators will be using a radioactive drug, \[18F\]MNI-558 that binds to beta-amyloid. This drug is experimental and has not been approved by the FDA. Brain imaging using PET (positron emission tomography) will be done to see if the investigators can evaluate the areas of beta-amyloid in the subjects with Alzheimer disease. The investigators will compare these scans with those done in healthy normal volunteers. PET is a brain-scanning test used in medicine and scientific research to see how the brain is working. The PET imaging test used in this study is not being done for diagnostic purposes.

Key facts

Study ID
NCT01217021
Run by
Institute for Neurodegenerative Disorders
People needed
10
Starts
2010-09-01
Expected to finish
2011-03-01
Last updated by the study team
2011-07-25

Who can join

Age: 55 and older. Sex: any. Healthy volunteers: accepted.

Where it is running

Full record on ClinicalTrials.gov

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