Clinical Evidence of pH Dependent ß2 Adrenergic Transport Mechanisms in the Airway

Completed · Not applicable

Conditions studied: Healthy Volunteers

In brief

The purpose of this study was to determine if airway pH has an effect on albuterol-induced vasodilation in the airway. Methods: Ten healthy volunteers performed the following respiratory maneuvers: quiet breathing, hypocapnic hyperventilation, hypercapnic hyperventilation, and eucapnic hyperventilation

Key facts

Study ID

NCT01216748

Run by

University of Miami

People needed

10

Starts

2010-01-01

Expected to finish

2010-08-01

Last updated by the study team

2016-05-27

Who can join

Age: 18 and older, up to 65. Sex: any. Healthy volunteers: accepted.

You may qualify if…

• Lifetime non-smokers
• FEV1 > 80% predicted value and FEV1/FVC > 0.75

You may not qualify if…

• Cardiovascular disease or use of cardiovascular or vasoactive drugs;
• Lung disease or use of airway drugs (i.e. inhaled corticosteroids, β adrenergic agonists);
• Respiratory infection during the 4 weeks preceding the study
• Use of systemic glucocorticoids within 4 weeks of the study
• Pregnant or nursing females

Where it is running

• Pulmonary Human Research Laboratory, University of Miami School of Medicine — Miami, Florida, United States

Full record on ClinicalTrials.gov

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