Bendamustine Hydrochloride and Rituximab With or Without Bortezomib Followed by Rituximab With or Without Lenalidomide in Treating Patients With High-Risk Stage II, Stage III, or Stage IV Follicular Lymphoma
Completed · Phase 2
Conditions studied: Lymphoma
In brief
RATIONALE: Drugs used in chemotherapy, such as bendamustine hydrochloride, work in different ways to stop the growth of cancer cells, either by killing the cells or by stopping them from dividing. Monoclonal antibodies, such as rituximab, can block cancer growth in different ways. Some block the ability of cancer cells to grow and spread. Others find cancer cells and help kill them or carry cancer-killing substances to them. Bortezomib may stop the growth of cancer cells by blocking some of the enzymes needed for cell growth. Biological therapies, such as lenalidomide, may stimulate the immune system in different ways and stop cancer cells from growing. It is not yet known whether giving bendamustine hydrochloride and rituximab together alone is more effective than giving bendamustine hydrochloride and rituximab together with bortezomib or lenalidomide in treating follicular lymphoma. PURPOSE: This randomized phase II trial is studying giving bendamustine hydrochloride and rituximab together with or without bortezomib followed by rituximab with or without lenalidomide to see how well they work in treating patients with high-risk stage II, stage III, or stage IV follicular lymphoma.
Key facts
- Study ID
- NCT01216683
- Run by
- ECOG-ACRIN Cancer Research Group
- People needed
- 289
- Starts
- 2011-02-09
- Expected to finish
- 2019-12-02
- Last updated by the study team
- 2023-06-29
Who can join
Age: 18 and older. Sex: any. Healthy volunteers: not accepted.
Where it is running
- Salinas Valley Memorial — Salinas, California, United States
- Stanford University Hospitals and Clinics — Stanford, California, United States
- The Medical Center of Aurora — Aurora, Colorado, United States
- Boulder Community Hospital — Boulder, Colorado, United States
- Rocky Mountain Cancer Centers-Boulder — Boulder, Colorado, United States
- Penrose-Saint Francis Healthcare — Colorado Springs, Colorado, United States
- Porter Adventist Hospital — Denver, Colorado, United States
- Exempla Saint Joseph Hospital — Denver, Colorado, United States
- Presbyterian - Saint Lukes Medical Center - Health One — Denver, Colorado, United States
- Rocky Mountain Cancer Centers-Midtown — Denver, Colorado, United States
- Rocky Mountain Cancer Centers-Rose — Denver, Colorado, United States
- Rose Medical Center — Denver, Colorado, United States
- Colorado Cancer Research Program CCOP — Denver, Colorado, United States
- Colorado Blood Cancer Institute — Denver, Colorado, United States
- Comprehensive Cancer Care and Research Institute of Colorado LLC — Englewood, Colorado, United States
- Swedish Medical Center — Englewood, Colorado, United States
- Poudre Valley Hospital — Fort Collins, Colorado, United States
- Mountain Blue Cancer Care Center — Golden, Colorado, United States
- North Colorado Medical Center — Greeley, Colorado, United States
- Rocky Mountain Cancer Centers-Greenwood Village — Greenwood Village, Colorado, United States
- Rocky Mountain Cancer Centers-Lakewood — Lakewood, Colorado, United States
- Saint Anthony Hospital — Lakewood, Colorado, United States
- Littleton Adventist Hospital — Littleton, Colorado, United States
- Rocky Mountain Cancer Centers-Sky Ridge — Lone Tree, Colorado, United States
- Marin Cancer Care Inc — Greenbrae, California, United States
Full record on ClinicalTrials.gov
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