Esmolol or Nitroglycerin Infusion for Blood Pressure Control Prior to Cardiopulmonary Bypass (CPB) in Cardiac Surgery
Completed · Not applicable
Conditions studied: Hypertension
In brief
This is an investigator initiated, sponsored, open label, prospective randomized controlled trial to be performed in adult patients undergoing scheduled cardiac surgery. Patients will be randomized to esmolol infusion or nitroglycerin infusion for control of hypertension that occurs during cardiac surgery from induction of anesthesia to initiation of cardiopulmonary bypass (CPB).
Key facts
- Study ID
- NCT01212874
- Run by
- Loma Linda University
- People needed
- 70
- Starts
- 2010-12-01
- Expected to finish
- 2014-06-01
- Last updated by the study team
- 2019-03-01
Who can join
Age: 18 and older, up to 85. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- adult patients scheduled for cardiac surgery at LLUMC University Hospital will be eligible for participation in this study.
You may not qualify if…
- severe LV (left ventricle)dysfunction (EF < 35%).
- emergency procedures.
- procedures with combined carotid artery surgery.
- patients at high risk for stroke.
- hemodynamically significant dysrhythmias.
- pre-existing atrial fibrillation or high degree AV (atrioventricular block).
- pacemaker dependency.
- known sensitivity to beta blockers.
- patient refusal.
Where it is running
- Loma Linda University — Loma Linda, California, United States
Full record on ClinicalTrials.gov
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