Axitinib For The Treatment Of Advanced Hepatocellular Carcinoma

Completed · Phase 2 · Has a placebo group

Conditions studied: Hepatocellular Carcinoma

In brief

The study is designed to demonstrate that axitinib plus best supportive care is superior to placebo plus best supportive care in prolonging survival in patients with advanced hepatocellular carcinoma.

Key facts

Study ID

NCT01210495

Run by

Pfizer

People needed

224

Starts

2010-12-06

Expected to finish

2016-12-20

Last updated by the study team

2019-01-09

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• Locally advanced or metastatic HCC
• Failure of one prior antiangiogenic therapy including sorafenib, bevacizumab and brivanib.
• Child-Pugh Class A or B (score 7 only) disease.

You may not qualify if…

• Prior treatment of advanced HCC with more than one prior first-line systemic therapy.
• Any prior local therapy within 2 weeks of starting the study treatment.
• Presence of hepatic encephalopathy and/or clinically relevant ascites.
• Presence of main portal vein invasion by HCC.

Where it is running

• UCSD Medical Center- La Jolla — La Jolla, California, United States
• Moores UCSD Cancer Center — La Jolla, California, United States
• University of California Irvine Medical Center — Orange, California, United States
• UCSD Medical Center- Hillcrest — San Diego, California, United States
• Florida Hospital Transplant Center, Liver Unit — Orlando, Florida, United States
• Moffitt Cancer Center & Research Institute — Tampa, Florida, United States
• University of Michigan — Ann Arbor, Michigan, United States
• Nebraska Methodist Hospital — Omaha, Nebraska, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Comprehensive Cancer Centers of Nevada — Las Vegas, Nevada, United States
• Hospital of the University of Pennsylvania — Philadelphia, Pennsylvania, United States
• Penn Presbyterian Medical Center — Philadelphia, Pennsylvania, United States
• Universitair Ziekenhuis Gent — Ghent, Belgium
• CHC Clinique Saint-Joseph — Liège, Belgium
• The First Affiliated Hospital of Anhui Medical University — Hefei, Anhui, China
• Guangdong General Hospital — Guangzhou, Guangdong, China
• Nanjing Bayi Hospital — Nanjing, Jiangsu, China
• Jiang Su Cancer Hospital — Nanjing, Jiangsu, China
• Sir Run Run Shaw Hospital of College of Medicine of Zhejiang University — Hangzhou, Zhejiang, China
• The PLA 307 Hospital — Beijing, China
• Zhongshan Hospital Fudan University — Shanghai, China
• Centre Hospitalier Universitaire d'Amiens — Amiens, France
• Hopital Saint André — Bordeaux, France
• CHU Cote de Nacre — Caen, France
• Alta Bates Summit Comprehensive Cancer Center — Berkeley, California, United States

Full record on ClinicalTrials.gov

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