Project CLEAR - Changing Lives by Eradicating Antibiotic Resistance

Completed · Not applicable

Conditions studied: Methicillin-resistant Staphylococcus Aureus

In brief

This randomized controlled trial will compare strategies to reduce the risk of methicillin-resistant Staphylococcus aureus (MRSA) infection and re-hospitalization in MRSA carriers. This trial will provide critical answers about the role of decolonization versus standard-of-care education in preventing MRSA infections in the large group of high risk MRSA-positive patients being discharged from hospitals. Findings could potentially impact best practice for the 1.8 million MRSA carriers who are discharged from US hospitals each year.

Key facts

Study ID

NCT01209234

Run by

University of California, Irvine

People needed

2140

Starts

2011-01-01

Expected to finish

2019-01-01

Last updated by the study team

2025-11-21

Who can join

Age: 18 and older. Sex: any. Healthy volunteers: not accepted.

You may qualify if…

• 1) At least 18 years old
• 2) Have had a positive culture (a type of test) for MRSA during recent hospital admission or within the 30 days prior to admission or following discharge
• 3) Able to give consent or have a primary caregiver provide consent
• 4) Able to bathe or shower or have this consistently performed by a willing caregiver

You may not qualify if…

• 1) Known allergies to chlorhexidine or mupirocin

Where it is running

• Covington Care Center — Aliso Viejo, California, United States
• West Anaheim Extended Care — Anaheim, California, United States
• Downey Regional Medical Center — Downey, California, United States
• Fountain Valley Regional Hospital & Medical Center — Fountain Valley, California, United States
• Orange Coast Memorial Medical Center — Fountain Valley, California, United States
• St. Jude Medical Center — Fullerton, California, United States
• Chapman Care Center — Garden Grove, California, United States
• Pacific Haven HealthCare Center — Garden Grove, California, United States
• Regents Point at Windcrest — Irvine, California, United States
• Saddleback Memorial Medical Center - Laguna Hills — Laguna Hills, California, United States
• Long Beach Memorial Medical Center — Long Beach, California, United States
• St. Mary Medical Center — Long Beach, California, United States
• Mission Hospital — Mission Viejo, California, United States
• Hoag Memorial Hospital Presbyterian — Newport Beach, California, United States
• Villa Elena Health Care Center — Norwalk, California, United States
• UC Irvine Medical Center — Orange, California, United States
• Saddleback Memorial Medical Center - San Clemente — San Clemente, California, United States
• Little Company of Mary - San Pedro — San Pedro, California, United States
• Country Villa Plaza — Santa Ana, California, United States
• Royale Healthcare — Santa Ana, California, United States
• Torrance Memorial Medical Center — Torrance, California, United States
• Providence Little Company of Mary Medical Center — Torrance, California, United States
• Harbor-UCLA Medical Center — Torrence, California, United States
• Ventura County Medical Center — Ventura, California, United States

Full record on ClinicalTrials.gov

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