Estrogen and Serotonin on Changing Brain Chemistry
Completed · Not applicable · Has a placebo group
Conditions studied: Menopause
In brief
The aim of this study is to examine the effects of estrogen and serotonin on cognition, emotional processing, and brain activation. The investigators will study the effects of acute tryptophan (TRP) depletion on cognition and mood in healthy menopausal women before and after estrogen replacement treatment (ERT). Using functional magnetic resonance imaging (fMRI), the investigators will identify differences in brain activation during memory tasks with and without TRP depletion and before and after estrogen therapy in order to determine which brain regions and cognitive functions are affected by each manipulation.
Key facts
- Study ID
- NCT01208324
- Run by
- University of Colorado, Denver
- People needed
- 47
- Starts
- 2010-03-04
- Expected to finish
- 2018-11-01
- Last updated by the study team
- 2021-04-02
Who can join
Age: 48 and older, up to 60. Sex: female. Healthy volunteers: accepted.
Where it is running
- Penn Center for Women's Behavioral Wellness, University of Pennsylvania — Philadelphia, Pennsylvania, United States
Full record on ClinicalTrials.gov
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