Mediators of Atherosclerosis in South Asians Living in America
Running, not enrolling
Conditions studied: Atherosclerosis, Cardiovascular Diseases, Heart Diseases, Coronary Artery Disease, Coronary Disease
In brief
South Asian (Indian, Pakistani, Bangladeshi, Nepali, and Sri Lankan) individuals have high rates of cardiovascular disease that is not explained by traditional cardiovascular risk factors. Though South Asians represent over one-quarter of the world's population, there are no longitudinal studies in this high-risk ethnic group. The investigators aim to establish a longitudinal study of South Asians at three United States centers to identify risk factors linked to subclinical atherosclerosis and incident cardiovascular disease. The purpose of this study is to understand the causes of heart disease and stroke in South Asians and compare these causes to those in other United States ethnic groups.
Key facts
- Study ID
- NCT01207167
- Run by
- University of California, San Francisco
- People needed
- 2314
- Starts
- 2010-09-01
- Expected to finish
- 2027-04-01
- Last updated by the study team
- 2026-01-26
Who can join
Age: 40 and older, up to 84. Sex: any. Healthy volunteers: not accepted.
You may qualify if…
- South Asian ancestry defined by having at least 3 grandparents born in one of the following countries: India, Pakistan, Bangladesh, Nepal, or Sri Lanka
- age between 40 and 84 years.
You may not qualify if…
- Physician diagnosed heart attack, stroke or transient ischemic attack (TIA), heart failure, or angina (or use of nitroglycerin)
- Current atrial fibrillation
- Past history of cardiovascular procedures (coronary artery bypass graft (CABG) Surgery, angioplasty, valve replacement, pacemaker or defibrillator implantation, or any surgery on the heart or arteries)
- Active treatment for cancer
- Life expectancy less than 5 years due to serious medical illness
- Impaired cognitive ability as judged by the reviewer
- Plans to move out of the study region in next 5 years
- Weight greater than 300 pounds
- Living in a nursing home or on a waiting list
- Unable to speak/read/write English, Hindi, Urdu, or Bangla
Where it is running
- University of California, San Francisco — San Francisco, California, United States
- Northwestern University — Chicago, Illinois, United States
- New York University — New York, New York, United States
Full record on ClinicalTrials.gov
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